ibuprofen

NSAID

indications

short term treatment of pain and inflammation

contra-indications

dogs, and probably cats

dose

horses: 25mg/kg po 3 times daily

ruminants: 15 - 25mg/kg po daily

toxic dose

dogs acute: 6 - 100mg/kg (gut)

cats are lower

chronic: more than 5mg/kg/day

note

no withholding times established

insulin

Soluble insulin

(Crystalline or neutral insulin)

rapid acting, short duration

used iv in emergencies, onset of action - immediate, maximum effect 30 mins - 2 hours, duration 1 - 4 hours (can be prolonged to 4 - 10 hr if given sc)

Insulin zinc suspension

(various mixtures of soluble and amorphous crystals complexed with zinc chloride)

Isophane insulin

(NPH)(complexed with protamine)

both intermediate acting, both given sc - onset 30 min - 3 hr, duration 4 - 24 hr depending on preparation

Protamine zinc insulin

longest acting - sc onset 2- 8 hr, duration 12 - 24 hr

indications

insulin dependent diabetes

dose protocols

Cats PZI 0.25-0.5iu/kg sc once daily (morning). Feed half the calories at the time of insulin administration and the other half 6-12 hours later. Unless the cat is sick, discharge it for 5-7 days then assess glucose curve. Aim to keep the glucose concentration 3.5-5.5 mM or below the renal threshold (about 10 mM in dogs, and 13 mM in cats) with a low of 4-5 mM.

Dogs isophane or PZI. Begin with 0.5 iu/kg once daily in the morning

diabetic ketoacidosis crystalline insulin 0.25 U/kg im initially then 0.1 iu/kg every hour for patients > 10 kg. If > 3 kg but < 10 kg give 2iu initially then 1iu/hour If < 3 kg give 1 U initially then 1 U q 1 hour. Once blood glucose is 13-14 mmol/l, add glucose to the intravenous fluids to 5%, and reduce insulin to q 6-8 hours.

iodide

20 or 50% sodium iodide solution

antimycotic

indications

actinobacillosis, actinomycosis

dose

cattle 66mg/kg sc or slow iv, repeat in 1 week

withholding times (Aus)

meat 28days, milk 10days

iodine 131 (radioactive)

antithyroid

indications

hyperthyroid cats

side effects

hypothyroidism

dose

based on clinical signs and total thyroxine concentration

Clinical signs, Score

mild, 1

moderate, 2

severe, 3

Total thyroxine

30-60 pM, 1

60-100, 2

> 100, 3

Thyroid size

not palpable, 1

<1.5 x 0.5, 2

>1.5 x 0.5, 3

bilateral, 3

Scores are added and dose calculated:

Score mBq

3,4,5: 39-60

6,7,8: 60-75

7,8,9: 75-100

reference

Radioiodine treatment of hyperthyroid cats. BR Jones, J Cayzer, EA Dillon, KP Smidt (1991) NZVJ 99 71-74 .

notes

radiation hazard, before using, read the Code of safe practice for the treatment of cats for thyroid disorders with iodine-131 Issued by: The National Radiation Laboratory, PO Box 25-099, Victoria Street, Christchurch

ipecacuanha

emetic

indications

suspected poisoning

dose

dogs 1 - 2mL/kg up to a maximum of 15mL

cats 2 - 6mL/cat

isoprenaline

isoproterenol USAN

ß adrenergic agonist

indications

(bradycardia)

side effects

tachycardia, tachyarrhythmias

contra-indications

congestive heart failure

dose

iv infusion - 0.045 - 0.09 µg/kg/min (dilute 0.2 mg in 1 litre of 5% dextrose which will give a concentration of 0.2 µg/ml)

notes

use a pacemaker instead