The cardiovascular system

The cardiovascular system is one integrated system - changing one aspect with drugs alters everything else. The system is normally controlled within very fine limits by a variety of mechanisms - a knowledge of cardiovascular physiology is essential to understand cardiovascular pharmacology and use cardiovascular drugs safely.

Possible areas of CVS failure

Organ   Problem Drugs used
heart conducting system
myocardium
blood supply
valves
neural control
arrhythmias
reduced contractility
ischaemia
regurgitation
rate
anti-arrhythmics
positive inotropes, vasodilators, diuretics
vasodilators, diuretics
vasodilators
chronotropes
blood vessels   hypertension vasodilators
blood volume
red blood cells
proteins
ions
hypovolaemia
haemorrhage
various problems
various problems
colloids (crystalloids)
whole blood
colloids, clotting factors
crystalloids