Antiarrhythmics
• Vaughan Williams classification
I - sodium channel blockers
Ia - atrial fibrillation
Ib - ventricular ectopic beats
II - beta blockers - stress induced tachycardias
III - not used much
IV - calcium channel blockers - atrial tachycardias
• other antiarrhythmics
digitalis - atrial fibrillation
adenosine - supraventricular tachycardias
calcium - ventricular tachycardia due to high potassium
commonly used drugs
Class 1
lignocaine, quinidine
Class 2
propranolol, atenolol
Class 4
verapamil, diltiazem
Others
atropine, adrenaline, digoxin, adenosine, calcium

Antiarrhythmics

Definitions

arrhythmias (= dysrhythmias) - abnormal cardiac rhythm. They may be abnormalities of impulse formation, conduction, rate or regularity and arise from delayed after-depolarisation or re-entry.

Arrhythmias may not affect the heart's efficiency as a pump and require no treatment, eg sinus arrhythmia which is normal in fit animals. Other arrhythmias eg ventricular fibrillation are immediately life threatening. Most arrhythmias fall between these extremes. (nb, all antiarrhythmic drugs decrease cardiac output to some extent, and may also cause arrhythmias, so you have to be sure that the presenting arrhythmia is worse for the animal than the treatment.) Treat the animal, not the ECG!!!

Causes

other heart disease
hereditary
autonomic system
metabolic disease

hypoxia
acidosis
electrolyte imbalance (particularly K+)

drug toxicity (including antiarrhythmics!)

A variety of mechanisms can give rise to arrythmias.

Vaughan Williams classification of antiarrhythmic drugs

Clinical use

diagram

Antiarrhythmics lecture