NSAIDs anti-pyretic action
Bacterial endotoxins can cause the release of interleukin 1 which stimulates the generation of PGE2 in the endothelium of the hypothalamic vasculature, which is thought to be the mechanism responsible for changing the bodies normal thermostatic control setting. The use of NSAIDs will not affect normal body temperature (except in cases of toxicity) nor will they affect exertionally induced hyperthermia. They will reduce pyrexia associated with pyrogens circulating in the plasma.
| 5 CNS index |
 |
 |
 |
 |
 |
 |
 |
copyright
Massey University
|